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Further, steroids that are primarily anabolic will not convert to estrogen as estrogen is a precursor to androgenic hormones. The endocannabinoid system may also play a role by acting as a signal to the brain to increase testosterone production. The endocannabinoid system may regulate the production and release of insulin-like growth factor-1 (IGF-1). IGF-1 acts as a signal to cells to grow and become more abundant, which can lead to increased muscle mass. For this reason, the body is concerned with the amount and type of IGF-1 in the bloodstream. Therefore, IGF-1 promotes weight loss. Studies also indicate that cannabinoids may influence the expression of IGF-1 and other IGF-signaling genes to facilitate or inhibit their action and increase or decrease IGF-1. In the human body, this pathway seems to activate the hypothalamus, where the IGF-1 gene is expressed and stimulates a variety of actions. This pathway is also a critical component in how the endocannabinoid system influences energy metabolism. Endocannabinoid receptors are located on the end of anandamide receptors. These receptors are thought to be central to regulating energy metabolism, muscle growth, fat cell hypertrophy, and insulin resistance by activating TOR, the TOR/PKB pathway of fatty acid oxidation and lipogenesis, which is essential to support fat cell function and help prevent muscle breakdown in the obese. This pathway also plays a key role in maintaining the integrity of cells and organs within the body. Endocannabinoid signals also play a critical role in insulin sensitization and insulin resistance Because of its ability to enhance energy metabolism via the androgen receptors and IGF-1 pathway (see above), and its ability to regulate energy metabolism through TOR/PKB and IGF-1 signaling, cannabinoids have been shown to play a significant role in the development of insulin resistance. In one study examining the relationship between CBN receptors and insulin sensitivity, researchers found that cannabinoids also increased insulin sensitivity in type 2 diabetics. Insulin resistance is a condition in which blood glucose levels are elevated in response to the consumption of high-fat diet; therefore, type 2 diabetic patients who receive insulin need to eat a small amount of protein to ensure that their insulin levels stay within a certain area. In addition to increasing insulin sensitivity, cannabinoids may help reduce blood glucose levels and the need for insulin. When high-fat diet is implemented for extended periods of time, the body may use it to provide energy or provide an alternative energy source for the body. To help the body keep from needing extra energy, it Related Article: